Mouse Nfkbia activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nfkbia
Locus ID	18035
Kit Components	GA202885G1, Nfkbia gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202885G2, Nfkbia gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202885G3, Nfkbia gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010907
Synonyms	AI462015; Nfkbi
Summary	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.[UniProtKB/Swiss-Prot Function]

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