Mouse Nfatc2ip activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nfatc2ip
Locus ID	18020
Kit Components	GA202872G1, Nfatc2ip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202872G2, Nfatc2ip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202872G3, Nfatc2ip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010900
Synonyms	D7Ertd304e; NIP45
Summary	In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.[UniProtKB/Swiss-Prot Function]

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