Mouse Mme activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mme
Locus ID	17380
Kit Components	GA202673G1, Mme gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202673G2, Mme gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202673G3, Mme gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289462, NM_001289463, NM_008604, NM_001357335
Synonyms	6030454K05Rik; C85356; CALLA; CD10; NEP; SFE
Summary	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).[UniProtKB/Swiss-Prot Function]

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