Mouse Marcksl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Marcksl1
Locus ID	17357
Kit Components	GA202671G1, Marcksl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202671G2, Marcksl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202671G3, Marcksl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010807
Synonyms	AL022768; AW215397; AW536807; D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp; Mrp
Summary	Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (PubMed:22751924). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (PubMed:22751924). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable).[UniProtKB/Swiss-Prot Function]

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