Mouse Mecp2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mecp2
Locus ID	17257
Kit Components	GA202627G1, Mecp2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202627G2, Mecp2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202627G3, Mecp2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081979, NM_010788
Synonyms	1500041B07Rik; D630021H01Rik; Mbd5; WBP10
Summary	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).[UniProtKB/Swiss-Prot Function]

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