Mouse Mgrn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mgrn1
Locus ID	17237
Kit Components	GA202617G1, Mgrn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202617G2, Mgrn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202617G3, Mgrn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252437, NM_029657, NM_001357061, NM_001357062
Synonyms	2610042J20Rik; md; mKIAA0544; nc
Summary	E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling (PubMed:29290584).[UniProtKB/Swiss-Prot Function]

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