Mouse Mcm4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mcm4
Locus ID	17217
Kit Components	GA202605G1, Mcm4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202605G2, Mcm4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202605G3, Mcm4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008565
Synonyms	19G; AI325074; AU045576; Cdc21; mcdc21; Mcmd4; mKIAA4003
Summary	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.[UniProtKB/Swiss-Prot Function]

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