Mouse Smad1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Smad1
Locus ID	17125
Kit Components	GA202544G1, Smad1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202544G2, Smad1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202544G3, Smad1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008539
Synonyms	AI528653; Madh1; Madr1; Mlp1; MusMLP
Summary	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).[UniProtKB/Swiss-Prot Function]

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