Mouse Jun activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Jun
Locus ID	16476
Kit Components	GA202239G1, Jun gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202239G2, Jun gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202239G3, Jun gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010591
Synonyms	AP-1; c-jun; Junc
Summary	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:14707112). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity).[UniProtKB/Swiss-Prot Function]

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