Mouse Ido1 activation kit by CRISPRa
CAT#: GA202058
Ido1 CRISPRa kit - CRISPR gene activation of mouse indoleamine 2,3-dioxygenase 1
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Ido1 |
Locus ID | 15930 |
Kit Components | GA202058G1, Ido1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202058G2, Ido1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202058G3, Ido1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001293690, NM_008324 |
Synonyms | Ido; Indo |
Summary | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (Ref. 3).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN308091 | Ido1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN308091BN | Ido1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN308091LP | Ido1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN308091RB | Ido1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12260.00 |
|
KN508091 | Ido1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |