Mouse Hsph1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hsph1
Locus ID	15505
Kit Components	GA202014G1, Hsph1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202014G2, Hsph1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202014G3, Hsph1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347534, NM_013559
Synonyms	105kDa; AI790491; hsp-E7I; Hsp105; Hsp110; hsp110/105
Summary	Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236).[UniProtKB/Swiss-Prot Function]

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