Mouse Hmgcl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hmgcl
Locus ID	15356
Kit Components	GA201919G1, Hmgcl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201919G2, Hmgcl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201919G3, Hmgcl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008254, NM_001357529, NM_001357530
Synonyms	AW476067; HL
Summary	Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.[UniProtKB/Swiss-Prot Function]

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