Mouse Cmklr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cmklr1
Locus ID	14747
Kit Components	GA201696G1, Cmklr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201696G2, Cmklr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201696G3, Cmklr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008153, NM_001359060
Synonyms	ChemR23; DEZ; Gpcr27; mcmklr1
Summary	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism.[UniProtKB/Swiss-Prot Function]

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