Mouse Gnat1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gnat1
Locus ID	14685
Kit Components	GA201655G1, Gnat1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201655G2, Gnat1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201655G3, Gnat1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008140
Synonyms	Gnat-1; Ird1; Ird2; irdc; irdr; Tralpha; transducin
Summary	Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity).[UniProtKB/Swiss-Prot Function]

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