Mouse Gabrb2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gabrb2
Locus ID	14401
Kit Components	GA201519G1, Gabrb2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201519G2, Gabrb2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201519G3, Gabrb2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347314, NM_008070, NM_001362646, NM_001362647, NM_001362649
Synonyms	AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2
Summary	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:20400944). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).[UniProtKB/Swiss-Prot Function]

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