Mouse Fnbp1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fnbp1
Locus ID	14269
Kit Components	GA201458G1, Fnbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201458G2, Fnbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201458G3, Fnbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001038700, NM_001177648, NM_001177649, NM_001177650, NM_019406, NM_001355105, NM_001355106
Synonyms	1110057E06Rik; 2210010H06Rik; FBP1; Fbp17
Summary	Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity).[UniProtKB/Swiss-Prot Function]

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