Mouse Fkbp8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fkbp8
Locus ID	14232
Kit Components	GA201433G1, Fkbp8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201433G2, Fkbp8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201433G3, Fkbp8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001111066, NM_001199631, NM_010223
Synonyms	38kDa; FKBP-8; FKBP-38; Fkbp38
Summary	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.[UniProtKB/Swiss-Prot Function]

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