Mouse Erbb3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Erbb3
Locus ID	13867
Kit Components	GA201283G1, Erbb3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201283G2, Erbb3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201283G3, Erbb3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010153
Synonyms	C76256; Erbb-3; Erbb3r; Her3
Summary	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.[UniProtKB/Swiss-Prot Function]

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