Mouse Dyrk1b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dyrk1b
Locus ID	13549
Kit Components	GA201157G1, Dyrk1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201157G2, Dyrk1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201157G3, Dyrk1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001037957, NM_001271370, NM_010092
Synonyms	Mirk
Summary	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).[UniProtKB/Swiss-Prot Function]

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