Mouse Cr1l activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cr1l
Locus ID	12946
Kit Components	GA200889G1, Cr1l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200889G2, Cr1l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200889G3, Cr1l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013499, NM_001355060, NM_001355061
Synonyms	Crry; Mcp; mCRY
Summary	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.[UniProtKB/Swiss-Prot Function]

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