Mouse Crhr2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Crhr2
Locus ID	12922
Kit Components	GA200874G1, Crhr2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200874G2, Crhr2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200874G3, Crhr2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001288618, NM_001288619, NM_001288620, NM_009953
Synonyms	CRF-R2; Crfr2; CRFR2alpha; CRFR2beta
Summary	G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.[UniProtKB/Swiss-Prot Function]

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