Mouse Cobl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cobl
Locus ID	12808
Kit Components	GA200799G1, Cobl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200799G2, Cobl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200799G3, Cobl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282993, NM_001282994, NM_172496
Synonyms	4732460E13; C530045F18Rik; mKIAA0633
Summary	Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells.[UniProtKB/Swiss-Prot Function]

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