Mouse Cntn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cntn1
Locus ID	12805
Kit Components	GA200797G1, Cntn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200797G2, Cntn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200797G3, Cntn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159647, NM_001159648, NM_007727, NM_001358051
Synonyms	AW495098; CNTN; F3cam; usl
Summary	Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.[UniProtKB/Swiss-Prot Function]

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