Mouse Bmpr1a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Bmpr1a
Locus ID	12166
Kit Components	GA200426G1, Bmpr1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200426G2, Bmpr1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200426G3, Bmpr1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009758
Synonyms	1110037I22Rik; ALK3; AU045487; Bmpr; BMPR-IA
Summary	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555).[UniProtKB/Swiss-Prot Function]

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