Mouse Atp8a1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atp8a1
Locus ID	11980
Kit Components	GA200340G1, Atp8a1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200340G2, Atp8a1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200340G3, Atp8a1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001038999, NM_001284345, NM_009727
Synonyms	AI481521; AI853962; APLT; Atp3a2; AW743152; AW822227; B230107D19Rik; ClassI
Summary	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells; the activity is associated with hippocampus-dependent learning.[UniProtKB/Swiss-Prot Function]

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