Mouse Gfer activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gfer
Locus ID	11692
Kit Components	GA200172G1, Gfer gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200172G2, Gfer gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200172G3, Gfer gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023040, NM_212443
Synonyms	Alr; ERV1
Summary	FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity).[UniProtKB/Swiss-Prot Function]

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