Mouse Acvrl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Acvrl1
Locus ID	11482
Kit Components	GA200056G1, Acvrl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200056G2, Acvrl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200056G3, Acvrl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612
Synonyms	Acvrlk1; AI115505; AI427544; Alk1
Summary	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.[UniProtKB/Swiss-Prot Function]

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