Human TMEM170B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMEM170B
Locus ID	100113407
Kit Components	GA119069G1, TMEM170B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA119069G2, TMEM170B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA119069G3, TMEM170B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001100829
Summary	Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600).[UniProtKB/Swiss-Prot Function]

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