Human AKR1B15 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AKR1B15
Locus ID	441282
Kit Components	GA118500G1, AKR1B15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA118500G2, AKR1B15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA118500G3, AKR1B15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001080538, NM_001367820, NM_001367821, NR_160301, NR_160302, NM_001367822
Synonyms	AK1R1B7; AKR1B10L; AKR1R1B7
Summary	Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).[UniProtKB/Swiss-Prot Function]

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