Human C7orf59 (LAMTOR4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LAMTOR4
Locus ID	389541
Kit Components	GA118059G1, C7orf59 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA118059G2, C7orf59 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA118059G3, C7orf59 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008395, NM_001318236, NM_001318237, NR_134526, NR_134527, NR_134528, NR_134529, NR_134530
Synonyms	C7orf59
Summary	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.[UniProtKB/Swiss-Prot Function]

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