Human SUMO4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SUMO4
Locus ID	387082
Kit Components	GA117874G1, SUMO4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117874G2, SUMO4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117874G3, SUMO4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002255
Synonyms	dJ281H8.4; IDDM5; SMT3H4; SUMO-4
Summary	This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

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