Human CERKL activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CERKL
Locus ID	375298
Kit Components	GA117810G1, CERKL gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117810G2, CERKL gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117810G3, CERKL gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001030311, NM_001030312, NM_001030313, NM_001030314, NM_001030315, NM_001160277, NM_201548, NR_027689, NR_027690
Synonyms	RP26
Summary	This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]

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