Human FAM195B (MCRIP1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MCRIP1
Locus ID	348262
Kit Components	GA117678G1, FAM195B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117678G2, FAM195B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117678G3, FAM195B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001093767, NM_001288798, NM_001288799, NM_207368
Synonyms	FAM195B; GRAN2; MCRIP
Summary	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).[UniProtKB/Swiss-Prot Function]

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