Human IRGM activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IRGM
Locus ID	345611
Kit Components	GA117613G1, IRGM gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117613G2, IRGM gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117613G3, IRGM gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001145805, NM_001346557
Synonyms	IFI1; IRGM1; LRG-47; LRG47
Summary	This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

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