Human NANOS3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NANOS3
Locus ID	342977
Kit Components	GA117556G1, NANOS3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117556G2, NANOS3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117556G3, NANOS3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001098622, NR_146095, NR_146096, NR_146097
Synonyms	NANOS1L; NOS3
Summary	Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.[UniProtKB/Swiss-Prot Function]

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