Human ATXN1L activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATXN1L
Locus ID	342371
Kit Components	GA117535G1, ATXN1L gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117535G2, ATXN1L gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117535G3, ATXN1L gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001137675, NR_024612
Synonyms	BOAT; BOAT1
Summary	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).[UniProtKB/Swiss-Prot Function]

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