Human TMEM119 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMEM119
Locus ID	338773
Kit Components	GA117390G1, TMEM119 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117390G2, TMEM119 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117390G3, TMEM119 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_181724
Synonyms	OBIF
Summary	Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).[UniProtKB/Swiss-Prot Function]

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