Human Endonuclease V (ENDOV) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ENDOV
Locus ID	284131
Kit Components	GA117102G1, Endonuclease V gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117102G2, Endonuclease V gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117102G3, Endonuclease V gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164637, NM_001164638, NM_173627, NM_001352760, NM_001352761, NR_148041, NR_148042, NR_148043, NR_148044, NR_148045
Synonyms	FLJ35220; MGC74455
Summary	Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.[UniProtKB/Swiss-Prot Function]

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