Human ASC2 (PYDC1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PYDC1
Locus ID	260434
Kit Components	GA116933G1, ASC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116933G2, ASC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116933G3, ASC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152901
Synonyms	ASC2; cPOP1; POP1; PYC1
Summary	Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.[UniProtKB/Swiss-Prot Function]

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