Human SVIP activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SVIP
Locus ID	258010
Kit Components	GA116902G1, SVIP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116902G2, SVIP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116902G3, SVIP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_148893, NM_001320340, NM_001320341, NM_001320342, NR_135213
Synonyms	DKFZp313A2432
Summary	Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

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