Human SERINC5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SERINC5
Locus ID	256987
Kit Components	GA116880G1, SERINC5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116880G2, SERINC5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116880G3, SERINC5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001174071, NM_001174072, NM_178276, NR_126060, NR_126061
Synonyms	C5orf12; TPO1
Summary	Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).[UniProtKB/Swiss-Prot Function]

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