Human IBRDC2 (RNF144B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF144B
Locus ID	255488
Kit Components	GA116827G1, IBRDC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116827G2, IBRDC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116827G3, IBRDC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_182757
Synonyms	bA528A10.3; IBRDC2; p53RFP; PIR2
Summary	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.[UniProtKB/Swiss-Prot Function]

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