Human ZDHHC20 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZDHHC20
Locus ID	253832
Kit Components	GA116759G1, ZDHHC20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116759G2, ZDHHC20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116759G3, ZDHHC20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001286638, NM_001330059, NM_153251, NR_104486, NR_104487
Synonyms	4933421L13Rik; DHHC-20
Summary	Catalyzes palmitoylation of Cys residues on target proteins (PubMed:27153536, PubMed:29326245). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).[UniProtKB/Swiss-Prot Function]

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