Human ZUP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZUP1
Locus ID	221302
Kit Components	GA116606G1, ZUP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116606G2, ZUP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116606G3, ZUP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_145062, NM_001361191, NR_154587, NR_154589, NM_001361189, NM_001361190, NR_154586, NR_154588
Synonyms	C6orf113; dJ412I7.3
Summary	This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]

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