Human SPATA13 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPATA13
Locus ID	221178
Kit Components	GA116598G1, SPATA13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116598G2, SPATA13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116598G3, SPATA13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001166271, NM_001286792, NM_001286793, NM_001286794, NM_001286795, NM_153023, NR_104595
Synonyms	ARHGEF29; ASEF2
Summary	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.[UniProtKB/Swiss-Prot Function]

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