Human MARCHF8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MARCHF8
Locus ID	220972
Kit Components	GA116580G1, MARCHF8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116580G2, MARCHF8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116580G3, MARCHF8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002265, NM_001002266, NM_001282866, NM_145021
Synonyms	c-MIR; MARCH-VIII; MIR; RNF178
Summary	MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

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