Human Munc 13 4 (UNC13D) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UNC13D
Locus ID	201294
Kit Components	GA116390G1, Munc 13 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116390G2, Munc 13 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116390G3, Munc 13 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_199242
Synonyms	FHL3; HLH3; HPLH3; Munc13-4
Summary	This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]

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