Human NLRP7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NLRP7
Locus ID	199713
Kit Components	GA116312G1, NLRP7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116312G2, NLRP7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116312G3, NLRP7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001127255, NM_139176, NM_206828
Synonyms	CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
Summary	This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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