Human CITED4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CITED4
Locus ID	163732
Kit Components	GA116095G1, CITED4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116095G2, CITED4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116095G3, CITED4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133467
Synonyms	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; OTTHUMP00000009206; transcriptional co-activator 4
Summary	The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

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