Human DENND1B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DENND1B
Locus ID	163486
Kit Components	GA116090G1, DENND1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116090G2, DENND1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116090G3, DENND1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142795, NM_001195215, NM_001195216, NM_001300858, NM_144977, NR_125340
Synonyms	C1orf218; DENN/MADD domain containing 1B; DKFZp547O0715; FAM31B; family with sequence similarity 31, member B; FLJ20054; FLJ21179; FLJ33888; MGC27044; MGC103810; RP11-53I24.2
Summary	Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

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